What Is Polmacoxib?
Polmacoxib is a selective COX‑2 inhibitor NSAID, also with mild carbonic anhydrase inhibition. Unlike non-selective NSAIDs, it’s designed to reduce pain and inflammation while minimizing gastrointestinal side effects
✅ Approved Uses
A). Primary – Osteoarthritis of the hip and knee: relieves pain, stiffness, and improves joint function
B). Other potential indications – Rheumatoid arthritis, ankylosing spondylitis, postoperative acute pain (e.g. dental, surgical), and menstrual pain
⚙️ Mechanism of Action
a). COX‑2 suppression lowers pro‑inflammatory prostaglandins, reducing pain and swelling.
b). Carbonic anhydrase uptake via red blood cells enhances delivery to inflamed joints, maintaining low systemic exposure
💊 Dosage & Administration
a). Typical dose: 2mg orally once daily with meals; do not exceed 2mg/day
b). Pharmacokinetics: T_max ~5–6 hours, half‑life ~130 hours, primarily fecal excretion
🧪 Efficacy & Clinical Trials
a). Demonstrated efficacy comparable to celecoxib in reducing WOMAC pain scores in Phase III osteoarthritis trials.
b). Higher doses (e.g. 4–8mg) showed dose-dependent benefits; 2mg is preferred for safety and effectiveness .
⚠️ Side Effects & Warnings
a). Common: headache, nausea, dyspepsia, dizziness, abdominal discomfort, diarrhea, peripheral edema
b). Serious but rare: gastrointestinal bleeding/ulcers; cardiovascular risks (e.g. hypertension, edema); hepatotoxicity/renal issues .
c). Contraindications/caution in: heart/kidney/liver disease, uncontrolled hypertension, peptic ulcer, NSAID allergy, third-trimester pregnancy, breastfeeding .
d). Drug interactions: anticoagulants (e.g. warfarin), ACE inhibitors, diuretics, lithium, methotrexate, corticosteroids, SSRIs .
e). Advice: take with food, avoid alcohol, use caution if driving (due to dizziness) .
💰 Regulatory Approval
In India, DCGI approved 2mg polmacoxib (Acelex) on February 14, 2023 for idiopathic primary osteoarthritis of hip and knee.
🏭 Elkos Healthcare & Polmacoxib 2mg
Elkos Healthcare is a WHO‑GMP & ISO 9001 certified pharma company in Haryana, offering capsules — including polmacoxib 2mg — via PCD pharma franchise and third-party manufacturing. Their Fawn Incor/Coxpol‑2 capsules are indicated for:
a). Osteoarthritis
b). Rheumatoid arthritis
c). Postoperative pain relief
Contact Elkos Healthcare
contact number: +91-96930-22222
Website: www.elkosgroup.in
Email: elkos7777@gmail.com
Address:Plot NO.246 HSIIDC Industrial EstateAlipur, Barwala, Panchkula-134118 Haryana, India.
💡 Final Thoughts
Polmacoxib 2mg offers targeted pain relief with a more favorable GI profile compared to non-selective NSAIDs. However, like all NSAIDs, it carries cardiovascular and renal risks—so use only as prescribed. Elkos Healthcare supplies quality polmacoxib capsules via their manufacturing and franchise channels.